Lefamulin and Antibiotic Combinations Against Enterococci
Author Information
Author(s): Min Yu-Hong, Kim Yong-ung, Park Min Chul
Primary Institution: Daegu Haany University and Inje University
Hypothesis
Can lefamulin combined with other antibiotics show synergistic effects against Enterococcus faecium and Enterococcus faecalis?
Conclusion
Lefamulin combined with doxycycline or rifampin shows strong synergistic effects against Enterococcus faecium and Enterococcus faecalis.
Supporting Evidence
- 85.3% of E. faecium strains showed synergy with lefamulin and doxycycline.
- 97.1% of E. faecium strains showed synergy with lefamulin and rifampin.
- 94.4% of vancomycin-resistant E. faecium strains showed synergy with lefamulin and doxycycline.
- 93.9% of E. faecalis strains showed synergy with lefamulin and doxycycline.
Takeaway
This study found that mixing a new antibiotic called lefamulin with other antibiotics can help fight certain tough bacteria that usually resist treatment.
Methodology
The study used checkerboard and time-kill assays to evaluate the synergistic effects of lefamulin with other antibiotics against clinical strains of Enterococcus.
Limitations
The study's results are based on in vitro tests and need clinical validation.
Participant Demographics
Clinical isolates of Enterococcus faecium and Enterococcus faecalis from hospitals in South Korea.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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