Protective Role of Phyllanthus Niruri Extract Against Heart Damage from Doxorubicin in Rats
Author Information
Author(s): Thippeswamy A.H.M., Shirodkar Akshay, Koti B.C., Sadiq A. Jaffar, Praveen D.M., Swamy A.H.M., Viswanatha Patil Mahesh
Primary Institution: K.L.E. University’s College of Pharmacy, Hubli, India
Hypothesis
Does the aqueous extract of Phyllanthus niruri protect against doxorubicin-induced myocardial toxicity in rats?
Conclusion
The study suggests that Phyllanthus niruri has a cardioprotective effect due to its antioxidant properties.
Supporting Evidence
- Doxorubicin caused significant increases in cardiac biomarkers indicating toxicity.
- Pretreatment with Phyllanthus niruri extract significantly reduced these biomarkers to normal levels.
- The extract improved antioxidant levels in the heart tissue.
Takeaway
This study found that a plant called Phyllanthus niruri can help protect the heart from damage caused by a cancer drug called doxorubicin.
Methodology
Rats were treated with doxorubicin and pretreated with Phyllanthus niruri extract, followed by monitoring of various cardiac biomarkers and histopathological analysis.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Healthy albino Wistar rats of either sex, weighing between 150 and 200 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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