rac-tert-Butyl 2-{5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-2,4-dioxo-1,3-thiazolidin-3-yl}acetate
2011
Crystal Structure of a Chiral Thiazolidinedione Compound
publication
Evidence: moderate
Author Information
Author(s): Hu Sixing, Liang Guojuan, Fang Dashu, Gan Yongjun, Hu Xiangnan
Primary Institution: Chongqing Medical University
Hypothesis
The study investigates the crystal structure of a chiral thiazolidinedione compound synthesized from rosiglitazone.
Conclusion
The compound crystallizes as a racemate in a centrosymmetric space group, forming a two-dimensional network through hydrogen bonds.
Supporting Evidence
- The compound is a chiral molecule with a stereogenic center.
- It crystallizes in a centrosymmetric space group as a racemate.
- Intermolecular hydrogen bonds link the molecules into a two-dimensional network.
Takeaway
The researchers made a new type of molecule and looked at how it was arranged in a crystal. They found that it forms a special pattern with other molecules.
Methodology
The compound was synthesized through a series of reactions involving rosiglitazone and tert-butyl chloroacetate, followed by crystallization.
Digital Object Identifier (DOI)
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