Study of Flavonoid Derivatives as Protein Kinase Inhibitors
Author Information
Author(s): Fassihi Afshin, Sabet Razieh
Primary Institution: Isfahan University of Medical Sciences and Health Services
Hypothesis
The study investigates the relationship between the molecular structure of flavonoid derivatives and their inhibitory activity against p56lck protein tyrosine kinase.
Conclusion
The study found that substituent electronic descriptors significantly impact the inhibitory activity of flavonoid derivatives against protein tyrosine kinase.
Supporting Evidence
- The GA-PLS model had a high statistical quality with R2 = 0.74 and Q2 = 0.61.
- Different QSAR models revealed significant impacts of substituent electronic descriptors on inhibitory activity.
- The study compared the predictive ability of MLR and GA-PLS methods, finding GA-PLS to be superior.
Takeaway
This study looks at how different flavonoid compounds can stop a specific protein from working, which might help in treating diseases.
Methodology
The study used multiple linear regression (MLR) and genetic algorithm partial least squares (GA-PLS) methods to analyze the data.
Limitations
The study may be limited by the specific set of flavonoid derivatives analyzed and the descriptors used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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