Polymorphisms in Cyclophilin A Gene and HIV-1 Infection
Author Information
Author(s): Rits Maarten A. N. van Dort, Karel A. Kootstra, Neeltje A.
Primary Institution: Academic Medical Center, University of Amsterdam
Hypothesis
Are polymorphisms in the regulatory regions of Cyclophilin A associated with susceptibility to HIV-1 infection and disease progression?
Conclusion
The A1650G polymorphism may protect against HIV-1 infection, while the 1604G allele is weakly associated with disease progression in drug users.
Supporting Evidence
- The prevalence of the 1650G allele was significantly higher in high-risk seronegative MSM than in HIV-1 infected MSM.
- Participants carrying the 1604G allele showed accelerated progression when viral RNA load was above 104.5 copies per ml.
- Polymorphisms C1604G and A1650G were not associated with survival time among MSM of the ACS.
Takeaway
This study looked at how certain gene changes might affect people's chances of getting HIV. It found that one gene change might help protect against the virus.
Methodology
Participants were screened for C1604G and A1650G polymorphisms, and their association with HIV-1 susceptibility and disease progression was analyzed.
Potential Biases
Potential selection bias in participant recruitment.
Limitations
The study may not be generalizable to populations outside of the Amsterdam Cohort.
Participant Demographics
Caucasian men who have sex with men (MSM) and intravenous drug users (DU).
Statistical Information
P-Value
0.03
Confidence Interval
1.05–3.14
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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