Estrogen and Schizophrenia: The Role of Glucose Metabolism
Author Information
Author(s): Olsen Line, Hansen Thomas, Jakobsen Klaus D, Djurovic Srdjan, Melle Ingrid, Agartz Ingrid, Hall Haakan, Ullum Henrik, Timm Sally, Wang August G, Jönsson Erik G, Andreassen Ole A, Werge Thomas
Primary Institution: Research Institute of Biological Psychiatry, Sct. Hans Hospital, Denmark
Hypothesis
Are variants of glycolytic genes associated with schizophrenia or gender-associated aspects of the illness?
Conclusion
Several gene variants in the Glycolysis were associated with schizophrenia in three independent samples, but the findings are weak and not resistant to correction for multiple testing.
Supporting Evidence
- Variants of MAPK14, PCK1, and FBP1 were nominally significantly associated with schizophrenia.
- Several haplotypes within the ENO2 gene showed elevated risk of schizophrenia.
- The study included a total of 765 patients and 1274 control subjects.
Takeaway
This study looked at how certain genes related to sugar processing might be linked to schizophrenia, but the results weren't strong enough to be sure.
Methodology
Genotyping of 185 SNPs in three independent case-control samples of Scandinavian origin.
Potential Biases
The selection procedure may be biased by the choice of clinical hypothesis used to filter the experimental data.
Limitations
The findings are weak and not resistant to correction for multiple testing.
Participant Demographics
The study included 765 patients and 1274 control subjects from Denmark, Sweden, and Norway.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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