Manganese(II) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure and Biological Activity
Author Information
Author(s): Dimiza Filitsa, Hatzidimitriou Antonios G., Psomas George
Primary Institution: Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, Greece
Hypothesis
The study investigates the biological activity of manganese(II) complexes with various non-steroidal anti-inflammatory drugs (NSAIDs) and their interactions with DNA and serum albumins.
Conclusion
The manganese(II) complexes exhibit significant antioxidant activity and strong interactions with DNA and serum albumins, suggesting potential for further biological studies.
Supporting Evidence
- Nine manganese(II) complexes were prepared and characterized.
- The complexes showed high antioxidant activity against ABTS radicals.
- Complex 7 had the highest DNA binding constant among the studied complexes.
- Complexes exhibited reversible binding to serum albumins.
- Most complexes were more effective than the corresponding free NSAIDs.
Takeaway
Scientists made special compounds using manganese and common painkillers to see if they could help fight diseases by being good at stopping bad stuff in our bodies.
Methodology
The complexes were synthesized and characterized using spectroscopic techniques and single-crystal X-ray crystallography, and their biological profiles were assessed through antioxidant activity tests and interactions with DNA and serum albumins.
Limitations
The study did not explore the long-term effects or potential side effects of the manganese(II) complexes in biological systems.
Digital Object Identifier (DOI)
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