New Benzofuran–Pyrazole Compounds as Antimicrobial Agents
Author Information
Author(s): Abd El-Karim Somaia S., Anwar Manal M., Syam Yasmin M., Awad Hassan M., El-Dein Asmaa Negm, El-Ashrey Mohamed K., Alkahtani Hamad M., Abdelwahed Sameh H.
Primary Institution: National Research Centre, Dokki, Cairo, Egypt
Hypothesis
This study aims to design, synthesize, and evaluate new benzofuran–pyrazole-based compounds for their antimicrobial, antioxidant, and anti-inflammatory properties.
Conclusion
The benzofuran–pyrazole-based compounds, particularly compound 9, show great potential as new antimicrobial agents due to their broad-spectrum activity and potent DNA gyrase B inhibition.
Supporting Evidence
- Compounds 9, 10, and 11b–d exhibited significant broad-spectrum antimicrobial activity with MIC values ranging from 2.50 to 20 µg/mL.
- Compounds 4, 6, 9, 11b, and 11d demonstrated high antioxidant activity, with DPPH scavenging percentages between 84.16% and 90.52%.
- Most compounds showed substantial anti-inflammatory effects, with HRBC membrane stabilization percentages ranging from 86.70% to 99.25%.
- Compound 9 notably inhibited E. coli DNA gyrase B with an IC50 of 9.80 µM, comparable to ciprofloxacin.
Takeaway
Scientists created new compounds that can fight germs and help reduce inflammation. One of these compounds, called compound 9, works really well against bacteria.
Methodology
New benzofuran–pyrazole hybrid molecules were synthesized and their antimicrobial activities were assessed against various bacterial and fungal strains, while antioxidant and anti-inflammatory properties were evaluated using specific assays.
Digital Object Identifier (DOI)
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