TEAM Trial on Unruptured Intracranial Aneurysms
Author Information
Author(s): Raymond Jean, Darsaut Tim E, Molyneux Andrew J
Primary Institution: Centre hospitalier de l'Université de Montréal (CHUM)
Hypothesis
Is endovascular treatment more effective than conservative management for unruptured intracranial aneurysms?
Conclusion
The TEAM trial was stopped due to poor recruitment, highlighting significant barriers in conducting clinical trials.
Supporting Evidence
- The trial aimed to recruit 2000 patients but only managed to enroll 80.
- Bureaucratic delays significantly hindered the trial's progress.
- Physicians were reluctant to recruit patients due to uncertainty about treatment benefits.
Takeaway
The TEAM trial tried to find out if treating unruptured brain aneurysms was better than doing nothing, but not enough people signed up to help.
Methodology
A prospective randomized trial comparing endovascular treatment and conservative management.
Potential Biases
Potential conflicts of interest among investigators and reluctance from physicians to question standard practices.
Limitations
The trial was stopped early due to insufficient recruitment and bureaucratic hurdles.
Participant Demographics
{"mean_age":56,"gender_distribution":{"female":65,"male":35},"history_of_sah":{"yes":10,"no":90}}
Digital Object Identifier (DOI)
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