The Role of Peroxisome Proliferator-Activated Receptors in the Development and Physiology of Gametes and Preimplantation Embryos
2008
The Role of PPARs in Gametes and Embryos
publication
Evidence: moderate
Author Information
Author(s): Jaou-Chen Huang
Primary Institution: University of Texas Medical School at Houston
Hypothesis
What are the physiological roles of peroxisome proliferator-activated receptors (PPARs) in gamete maturation and embryo development?
Conclusion
PPARs play a crucial role in optimizing gamete function and embryo development.
Supporting Evidence
- PPARs are expressed in both somatic and germ cells of the ovary and testis.
- PPARγ ligands have been used to induce ovulation in women with polycystic ovary disease.
- Disruption of PPARγ in the ovary can lead to female subfertility.
- PPARβ/δ activation enhances embryo development and implantation rates.
Takeaway
PPARs are important for helping eggs and embryos grow properly, and they can be affected by certain chemicals.
Methodology
This review summarizes existing knowledge on PPARs and their functions in reproduction.
Limitations
The literature on PPARs in gametes and preimplantation embryos is relatively limited.
Digital Object Identifier (DOI)
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