CD40 Gene Polymorphisms and Breast Cancer Risk in Chinese Women
Author Information
Author(s): Shuang Chen, Dalin Li, Weiguang Yuan, Zhenkun Fu, Fengyan Xu, Da Pang, Li Dianjun
Primary Institution: Harbin Medical University
Hypothesis
Do polymorphisms in the CD40 gene influence the risk of sporadic breast cancer?
Conclusion
CD40 gene polymorphisms are associated with an increased risk of sporadic breast cancer and correlate with certain clinical features in Chinese Han women.
Supporting Evidence
- Four SNPs in the CD40 gene were significantly associated with breast cancer risk.
- Patients with certain CD40 genotypes had higher rates of lymph node metastasis.
- The study included a large sample size of both patients and controls.
- Statistical significance was maintained after correcting for multiple testing.
Takeaway
This study found that certain changes in the CD40 gene can make women more likely to get breast cancer, and these changes are linked to how the cancer behaves.
Methodology
A case-control study genotyping four SNPs in 591 breast cancer patients and 600 healthy controls using PCR-RFLP.
Potential Biases
Potential selection bias in the recruitment of healthy controls.
Limitations
The study is limited to a specific population and may not be generalizable to other ethnic groups.
Participant Demographics
591 breast cancer patients and 600 age-matched healthy controls from Heilongjiang Province, China.
Statistical Information
P-Value
0.0012, 0.0013, 0.0279
Confidence Interval
[1.022, 1.445], [1.066, 1.499], [1.025, 1.454]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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