Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States
2006

Air Travel and Influenza Spread

Sample size: 396506 publication 10 minutes Evidence: high

Author Information

Author(s): Brownstein John S, Wolfe Cecily J, Mandl Kenneth D

Primary Institution: Children's Hospital Informatics Program at the Harvard–MIT Division of Health Sciences and Technology

Hypothesis

Does airline travel influence the spread of influenza across regions in the United States?

Conclusion

Airline travel significantly affects the timing and rate of influenza spread in the US.

Supporting Evidence

  • Domestic airline travel volume in November predicts the rate of influenza spread.
  • International airline travel influences the timing of influenza mortality.
  • The flight ban after September 11, 2001, delayed the influenza season.
  • Influenza spread was slower during years with lower domestic air travel.
  • Peak influenza mortality was delayed in years with lower international air travel.

Takeaway

When lots of people fly, the flu spreads faster. After 9/11, fewer flights meant the flu took longer to spread.

Methodology

Analyzed weekly mortality data from the CDC for nine influenza seasons and correlated it with airline travel data.

Potential Biases

Possible underreporting of deaths and variations in data quality across regions.

Limitations

Variability in reporting and potential inaccuracies in mortality data.

Participant Demographics

Data from multiple geographic regions in the United States.

Statistical Information

P-Value

0.014

Confidence Interval

95% confidence interval: 9.1–52.4 d

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pmed.0030401

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