Electrochemical Immunosensor for Early Prostate Cancer Detection
Author Information
Author(s): Cotchim Suparat, Kongkaew Supatinee, Thavarungkul Panote, Kanatharana Proespichaya, Limbut Warakorn
Primary Institution: Prince of Songkla University
Hypothesis
Can an unlabeled electrochemical immunosensor using activated carbon from marigold flowers and graphene quantum dots effectively detect prostate-specific antigen (PSA) for early prostate cancer diagnosis?
Conclusion
The developed immunosensor accurately quantified PSA levels in human serum, demonstrating its potential for early prostate cancer detection.
Supporting Evidence
- The immunosensor exhibited two linear ranges for PSA detection: 0.0125 to 1.0 ng mL−1 and 1.0 to 80.0 ng mL−1.
- The sensor could detect PSA concentrations as low as 0.005 ng mL−1.
- The developed immunosensor showed a limit of quantification of 0.017 ng mL−1.
- The results were validated using enzyme-linked fluorescence assay (ELFA).
- The immunosensor maintained over 90% of its optimal performance for 12 weeks.
Takeaway
This study created a special sensor that can find a protein called PSA in blood, which helps doctors check for prostate cancer early.
Methodology
The immunosensor was fabricated using activated carbon from marigold flowers and graphene quantum dots, followed by the immobilization of anti-PSA antibodies.
Statistical Information
P-Value
1.157 ± 0.006 × 10−10 mol L−1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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