Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis
2011
Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis
publication
Evidence: moderate
Author Information
Author(s): Sandeep Singh, Smitha Pillai, Srikumar Chellappan
Primary Institution: H. Lee Moffitt Cancer Center and Research Institute
Hypothesis
Nicotinic acetylcholine receptors contribute to the growth, progression, and metastasis of various cancers.
Conclusion
Nicotine promotes tumor growth and metastasis through signaling pathways involving nicotinic acetylcholine receptors.
Supporting Evidence
- Nicotine enhances cell proliferation and survival in various cancer types.
- Nicotinic acetylcholine receptors are involved in tumor angiogenesis.
- Chronic exposure to nicotine can lead to resistance to cancer therapies.
- Nicotine induces epithelial to mesenchymal transition in cancer cells.
- Studies show that nicotine can enhance the growth and metastasis of lung tumors.
Takeaway
Nicotine, found in tobacco, helps cancer cells grow and spread by using special receptors in our body.
Methodology
The paper reviews historical data and recent studies on the effects of nicotine on tumor growth and metastasis.
Limitations
The direct role of nicotine alone in tumorigenesis is not well explored.
Digital Object Identifier (DOI)
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