Using Carbon Nanotubes to Deliver Senna Leaf Extract for Breast Cancer Treatment
Author Information
Author(s): Behairy Sabreen Mohammed, Al-Maaqar Saleh Mohammed, Al-Shaeri Majed Ahmed
Primary Institution: King Abdulaziz University, Jeddah, Saudi Arabia
Hypothesis
Can single-walled carbon nanotubes (SWCNTs) effectively deliver senna leaf extract to induce apoptosis in breast cancer cells?
Conclusion
The study found that the combination of SWCNTs and senna leaf extract effectively induces apoptosis in breast cancer cells.
Supporting Evidence
- The combination of SWCNTs and senna leaf extract inhibited the viability of MCF7 cells in a dose-dependent manner.
- Cells treated with the combination showed significant morphological changes indicative of apoptosis.
- Elevated levels of reactive oxygen species (ROS) were observed in treated cells, suggesting oxidative stress.
- DNA damage was confirmed through comet assays, indicating the effectiveness of the treatment.
Takeaway
This study shows that using tiny tubes called carbon nanotubes to deliver a plant extract can help kill breast cancer cells.
Methodology
The study used MTT assays, comet assays, and Giemsa staining to assess cell viability, DNA damage, and morphological changes in breast cancer cells treated with SWCNTs and senna leaf extract.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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