Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
1997
Cell Damage and Antiphospholipid Antibodies in Pregnancy Loss
publication
Author Information
Author(s): V6ronique Piroux, Val6rie Eschwge, Jean-Marie Freyssinet
Primary Institution: Institut d'Hgmatologie et d'Immunologie, Facultg de Mgdecine, Universitg Louis Pasteur
Hypothesis
Do antiphospholipid antibodies occur in response to sustained exposure of thrombogenic phospholipid surfaces?
Conclusion
Antiphospholipid antibodies may lead to increased thrombotic risk and recurrent pregnancy loss due to their interaction with cell membrane components.
Supporting Evidence
- Antiphospholipid antibodies are associated with thrombosis and fetal loss.
- Cell apoptosis and necrosis may lead to the generation of antiphospholipid antibodies.
- Annexin V levels are reduced on placental villi from women with antiphospholipid-antibody syndrome.
Takeaway
This study looks at how certain antibodies can cause problems during pregnancy by affecting blood clotting.
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