Predictors of High-Grade Atherosclerotic Renal Artery Stenosis in Patients with CKD
Author Information
Author(s): Jun Ouyang, Kequan Chen, Hui Wang, Jiangnan Huang
Primary Institution: The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Hypothesis
This study aims to explore predictors of high-grade atherosclerotic renal artery stenosis (ARAS) in patients with chronic kidney disease (CKD).
Conclusion
In patients with CKD, eGFR, cystatin C, and LMR are predictive parameters of high-grade ARAS, with eGFR and LMR showing the greatest predictive value.
Supporting Evidence
- eGFR, cystatin C, and LMR were significantly associated with high-grade ARAS.
- ROC analysis showed that eGFR had an AUC of 0.681, indicating moderate predictive ability.
- Cystatin C levels were higher in patients with high-grade ARAS compared to those with low-grade ARAS.
Takeaway
Doctors can use certain blood tests to help figure out if patients with kidney problems have serious artery blockages.
Methodology
This was a retrospective study analyzing clinical data from 103 patients with CKD who underwent renal arteriography.
Potential Biases
Potential biases may arise from the retrospective nature of the study and the specific population studied.
Limitations
The study is retrospective, single-centered, and has a small sample size, which may limit the generalizability of the findings.
Participant Demographics
The average age of participants was 64.33 years, with a majority having a history of hypertension and coronary artery disease.
Statistical Information
P-Value
P = .017 for eGFR, P = .021 for cystatin C, P = .035 for LMR.
Confidence Interval
95% CI: 0.962–0.996 for eGFR, 95% CI: 1.118–4.030 for cystatin C, 95% CI: 0.421–0.969 for LMR.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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