Effects of CLA and VA on Lipid Levels in Rats
Author Information
Author(s): Jacome-Sosa M Miriam, Lu Jing, Wang Ye, Ruth Megan R, Wright David C, Reaney Martin J, Shen Jianheng, Field Catherine J, Vine Donna F, Proctor Spencer D
Primary Institution: University of Alberta
Hypothesis
Chronic supplementation with both CLA and VA would enhance the lipid lowering effects to improve whole body lipid metabolism.
Conclusion
The hypolipidemic effects of chronic cis-9, trans-11 CLA supplementation are enhanced by the addition of VA in the JCR:LA-cp rat.
Supporting Evidence
- Rats fed the VA+CLA diet had lower plasma triglyceride and LDL-cholesterol levels compared to the control group.
- The VA+CLA diet reduced liver weight and triglyceride content compared to the control diet.
- Citrate synthase activity was increased in liver and adipose tissue of rats fed CLA and VA+CLA diets.
Takeaway
This study found that giving certain fats to rats can help lower bad fat levels in their blood and liver.
Methodology
Twenty-four obese JCR:LA-cp rats were randomized into three diet groups for 16 weeks to assess the effects of CLA and VA on lipid levels.
Participant Demographics
Male obese JCR:LA-cp rats
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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