Successful Treatment of Fusariosis in a Child with Leukemia
Author Information
Author(s): Vagace José-Manuel, Sanz-Rodriguez Cesar, Casado Maria-Soledad, Alonso Nieves, Garcia-Dominguez Manuel, de la Llana Francisco Garcia, Zarallo Luis, Fajardo Miguel, Bajo Roberto
Primary Institution: Complejo Hospitalario Infanta Cristina, Badajoz, Spain
Hypothesis
Combination antifungal therapy likely contributed to the successful treatment of the patient's severe invasive fusariosis.
Conclusion
The case demonstrates successful treatment of disseminated fusariosis in a pediatric patient with acute lymphoblastic leukemia using a combination of antifungal therapies.
Supporting Evidence
- The patient was in complete remission following chemotherapy before the infection.
- Blood cultures yielded Fusarium spp. despite initial antifungal treatment.
- Clinical improvement was observed after initiating caspofungin therapy.
Takeaway
A girl with leukemia got very sick from a fungus, but after doctors gave her two antifungal medicines together, she got better and stayed healthy.
Methodology
The patient was treated with liposomal amphotericin B and caspofungin, followed by oral voriconazole.
Limitations
The effect of caspofungin in the successful outcome is not completely clear, and further studies are warranted.
Participant Demographics
An 11-year-old female with acute lymphoblastic leukemia.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website