Study on Perfluorinated Compounds in Drinking Water and Blood Plasma
Author Information
Author(s): Hölzer Jürgen, Midasch Oliver, Rauchfuss Knut, Kraft Martin, Reupert Rolf, Angerer Jürgen, Kleeschulte Peter, Marschall Nina, Wilhelm Michael
Primary Institution: Ruhr-University Bochum, Germany
Hypothesis
What are the levels of perfluorinated compounds (PFCs) in blood plasma of residents exposed to contaminated drinking water compared to a reference population?
Conclusion
PFC concentrations in blood plasma of children and adults exposed to PFC-contaminated drinking water were increased 4- to 8-fold compared with controls.
Supporting Evidence
- PFOA was the main compound found in drinking water at levels of 500-640 ng/L.
- PFOA levels in blood plasma were 4.5-8.3 times higher in Arnsberg compared to controls.
- PFHxS concentrations were significantly increased in Arnsberg compared to controls.
- PFBS was detected in 33% of children in Arnsberg compared to 5% in reference areas.
- Consumption of tap water was a significant predictor of PFOA blood concentrations.
Takeaway
This study found that people drinking contaminated water had much higher levels of certain chemicals in their blood than those who didn't drink the contaminated water.
Methodology
A cross-sectional study measuring PFC levels in blood plasma and drinking water samples from residents in Arnsberg, Germany.
Potential Biases
Self-reported data on water consumption may be subject to over- or underreporting.
Limitations
The study was conducted after public awareness of contamination, which may have influenced participants' water consumption behaviors.
Participant Demographics
Included 170 children (ages 5-6), 317 mothers (ages 23-49), and 204 men (ages 18-69).
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI for geometric means provided in the results.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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