SAFETY AND EFFECTS OF HEAT-INACTIVATED LACTOBACILLUS PARACASEI D3.5 (LPD3.5) ON MENTAL WELLBEING IN OLDER ADULTS
2024

Effects of Heat-Inactivated Lactobacillus on Mental Wellbeing in Older Adults

Sample size: 13 publication Evidence: low

Author Information

Author(s): Lloyd Amanda, Warren-Walker Alina, Holt Nigel, Lynch Doug, Kay Denis, Stephens Kevin, Jain Shalini, Yadav Hariom

Primary Institution: Aberystwyth University

Hypothesis

Does heat-inactivated Lactobacillus paracasei D3.5 improve mental wellbeing in older adults?

Conclusion

The study found that PoZibio was safe and well-tolerated, with improvements in emotional wellbeing and gastrointestinal symptoms.

Supporting Evidence

  • The study tested a postbiotic in older adults to assess its safety and impact on wellbeing.
  • Participants reported improvements in emotional wellbeing and gastrointestinal symptoms.

Takeaway

Older adults took a special supplement for a month, and it helped them feel better emotionally and improved their stomach health.

Methodology

Participants consumed four LpD3.5/PoZibio capsules daily and completed surveys before and after the study.

Potential Biases

The open-label design may introduce bias in the results.

Limitations

The study's open-label design, small sample size, and short duration limit the interpretation of the findings.

Participant Demographics

Healthy older adults aged 50 and above.

Digital Object Identifier (DOI)

10.1093/geroni/igae098.4069

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