Serum Gastrin Levels in Gastric Cancer Patients
Author Information
Author(s): S. Rakic, M.N. Milicevic
Primary Institution: Institute of Digestive Diseases, Belgrade University School of Medicine
Hypothesis
Does the histologic type of gastric cancer affect serum gastrin levels?
Conclusion
Patients with gastric cancer, especially of the intestinal type, have higher serum gastrin levels compared to normal subjects.
Supporting Evidence
- Gastrin levels in patients with intestinal gastric cancer were significantly higher than in controls.
- Gastrin levels in patients with diffuse gastric cancer were also higher than in controls.
- 63% of patients with intestinal gastric cancer had elevated gastrin levels compared to the control group.
Takeaway
People with stomach cancer have more of a substance called gastrin in their blood, especially if their cancer is of a certain type.
Methodology
Fasting serum gastrin levels were measured in patients with gastric cancer and normal subjects using radioimmunoassay.
Limitations
The study excluded patients with potential causes for hypergastrinemia, which may limit the generalizability of the findings.
Participant Demographics
61 patients with gastric cancer (20 diffuse type, 41 intestinal type) and 26 normal subjects.
Statistical Information
P-Value
0.07
Statistical Significance
p<0.00001
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