Salivary Cytokines in Burning Mouth Syndrome
Author Information
Author(s): Daria Simčić, Sonja Pezelj-Ribarić, Renata Gržić, Jelena Horvat, Gordana Brumini, Miranda Muhvić-Urek
Primary Institution: School of Dentistry, Medical Faculty, University of Rijeka
Hypothesis
The study aims to evaluate levels of salivary IL-2 and IL-6 in patients with Burning Mouth Syndrome (BMS) compared to healthy volunteers.
Conclusion
Patients with Burning Mouth Syndrome have significantly higher levels of IL-2 and IL-6 in their saliva compared to healthy individuals.
Supporting Evidence
- IL-2 levels in BMS patients were significantly higher than in healthy subjects.
- IL-6 levels in BMS patients were also significantly elevated compared to controls.
- The study used a control group of healthy individuals for comparison.
- Both cytokines were measured using enzyme immunoassay techniques.
Takeaway
People with Burning Mouth Syndrome have more of certain substances in their saliva that might be linked to their pain.
Methodology
Saliva samples from 30 patients with BMS and 30 healthy controls were analyzed for IL-2 and IL-6 using enzyme immunoassay.
Limitations
The study does not establish causation between cytokine levels and BMS symptoms.
Participant Demographics
30 patients with BMS aged 55-65 and 30 age-matched healthy volunteers.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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