Controlled Release of Nifedipine and Metoprolol Using Osmotic Pump Tablets
Author Information
Author(s): Kumaravelrajan Rajagopal, Narayanan Nallaperumal, Suba Venkatesan
Primary Institution: C.L. Baid Metha College of Pharmacy
Hypothesis
Can a controlled porosity osmotic pump tablet effectively deliver Nifedipine and Metoprolol in a controlled manner for hypertension treatment?
Conclusion
The developed osmotic system is effective in the multi-drug therapy of hypertension by delivering both drugs in a controlled manner.
Supporting Evidence
- The osmotic pump tablets can deliver drugs for up to 12 hours.
- Drug release was found to be independent of pH and gastrointestinal motility.
- The formulation showed a zero-order release pattern.
Takeaway
This study created a special tablet that can slowly release two medicines, Nifedipine and Metoprolol, to help people with high blood pressure.
Methodology
The study involved preparing controlled porosity osmotic pump tablets and evaluating their drug release characteristics using various formulation variables.
Digital Object Identifier (DOI)
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