2S Albumin Storage Proteins and Food Allergens
Author Information
Author(s): Moreno F. Javier, Clemente Alfonso
Primary Institution: Instituto de Fermentaciones Industriales (CSIC)
Hypothesis
What makes 2S albumin storage proteins major food allergens?
Conclusion
2S albumins are stable proteins that can sensitize the immune system and elicit allergic responses due to their ability to resist digestion in the gastrointestinal tract.
Supporting Evidence
- 2S albumins are major food allergens found in various seeds.
- These proteins can bind IgE from allergic patients' sera.
- 2S albumins are resistant to digestion in the gastrointestinal tract.
Takeaway
Some proteins in seeds can make people allergic. They are tough and can survive in our stomach, which helps them cause allergies.
Methodology
This review summarizes biochemical, structural, and functional properties of 2S albumins and their role in allergenicity.
Limitations
The role of conformational epitopes in allergenicity is not well understood and requires further investigation.
Digital Object Identifier (DOI)
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