PROBING THE GOLD BINDING SITE IN SERUM ALBUMIN
Studying Gold Binding in Serum Albumin
publication
Author Information
Author(s): Rodney E. Sue, Peter J. Sadler, Alan Tucker
Primary Institution: Birkbeck College, University of London
Hypothesis
The study investigates how different gold complexes bind to serum albumin.
Conclusion
The research reveals that various gold complexes induce structural changes in serum albumin.
Supporting Evidence
- Over 80% of the gold in the blood is carried by serum albumin.
- Previous studies have shown that the gold binds to cysteine-34 in domain of albumin.
Takeaway
This study looks at how gold from a medicine binds to a protein in our blood, which helps us understand how the medicine works.
Methodology
The binding of gold complexes to serum albumin was studied using 1H and 31P NMR spectroscopy.
Want to read the original?
Access the complete publication on the publisher's website