Systemic Vasoconstriction and Mortality in Heart Failure Patients
Author Information
Author(s): Marcelo Eidi Ochiai, Kelly Regina Vieira Novaes, Lucas Hideki Kato Myakava, Marcelo Villaça Lima, Euler Cristovan Brancalhão, Juliano Novaes Cardoso, Solange de Sousa Andrade, Wilson Jacob Filho, Antonio Carlos Pereira Barretto
Primary Institution: Heart Institute (InCor), University of São Paulo, São Paulo City, SP, Brazil
Hypothesis
This study aimed to evaluate the prognostic significance of systemic vasoconstriction in patients with decompensated heart failure with a reduced ejection fraction.
Conclusion
Non-invasive hemodynamic monitoring identifies systemic vasoconstriction, which is associated with poor prognosis in patients with advanced heart failure and reduced ejection fraction.
Supporting Evidence
- 87.9% of patients died over an average follow-up of 29 months.
- High systemic vascular resistance indices were predictive of mortality with a relative risk of 3.9.
- Patients with higher systemic vascular resistance had worse renal function and higher serum BNP levels.
Takeaway
Doctors can use a special test to see how blood vessels are working in heart failure patients, which helps predict who might get worse.
Methodology
Patients hospitalized for decompensated heart failure with a left ventricular ejection fraction of < 40% underwent non-invasive hemodynamic monitoring using the Modelflow method.
Limitations
The sample size was small and included patients with advanced heart failure, characterized by a high mortality rate.
Participant Demographics
58 patients (71% men) with a mean age of 58.9 years, an ejection fraction of 23.4%, and 43% with Chagas disease.
Statistical Information
P-Value
0.037
Confidence Interval
95% CI = 1.1–13.9
Statistical Significance
p=0.037
Digital Object Identifier (DOI)
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