Potential Antimicrobial and Cytotoxic Activity of Caralluma indica Seed Extract
Author Information
Author(s): Ramalingam Shunmuga Vadivu, Bakthavatchalam Senthil, Ramachandran Karnan, Gnanarani Soloman Vasthi, Ajmal Afrin Khan, Al-Sadoon Mohammad Khalid, Vinayagam Ramachandran, Zaharieva Maya, Najdenski Hristo
Primary Institution: Department of Biochemistry, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, India
Hypothesis
This study investigates the phytochemical composition of the ethanolic extract obtained from Caralluma indica seeds and assesses its antimicrobial, anticancer, and antioxidant activities.
Conclusion
C. indica seeds are promising candidates for combating oral pathogens, inhibiting biofilm formation, and reducing the risk of oral cancer progression.
Supporting Evidence
- GC-MS analysis found 30 phytochemicals in C. indica seeds, including 5 bioactive compounds with antioxidant, antimicrobial, and cytotoxic properties.
- C. indica exhibited robust antioxidant capacity and potent antimicrobial activity against oral pathogens.
- The extract significantly reduced biofilm formation against oral pathogens.
- Molecular docking studies showed a strong correlation between antifungal and anticancer targets.
Takeaway
The seeds of the Caralluma indica plant can help fight germs that cause oral infections and may also help prevent oral cancer.
Methodology
The study used GC-MS analysis to identify phytochemicals, in vitro assays to evaluate antioxidant and antimicrobial activities, and molecular docking studies to assess interactions with targets.
Potential Biases
The study does not mention any risks of bias.
Limitations
The study does not specify the limitations.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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