Epilepsy and Neurological Complications in Children with Hemophilia
Author Information
Author(s): Muacevic Alexander, Adler John R, Eguchi Yuta, Ishikawa Nobutsune, Kobayashi Yoshiyuki, Mizoguchi Yoko, Okada Satoshi
Primary Institution: Hiroshima University Hospital
Hypothesis
What are the characteristics of hemophilia patients with epilepsy caused by intracranial hemorrhage?
Conclusion
Epilepsy can develop in pediatric patients with hemophilia even without severe neurological abnormalities.
Supporting Evidence
- 9.8% of patients with hemophilia had intracranial hemorrhage.
- Epilepsy was observed in 3.9% of patients with ICH.
- Imaging studies are important for patients with hemophilia and epilepsy.
- Two patients with ICH experienced focal epilepsy with tonic-clonic seizures.
- None of the patients with ICH had severe neurological complications.
Takeaway
Some kids with hemophilia can have seizures even if they don't seem to have any other serious problems. Doctors need to check for brain injuries in these kids.
Methodology
Retrospective case series based on medical records of pediatric patients with hemophilia.
Potential Biases
Possibility of misclassification of asymptomatic ICH cases.
Limitations
Small sample size and potential selection bias due to being a single-center study.
Participant Demographics
51 male patients with hemophilia, median age at first visit was 1.1 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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