Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation
2000
Effects of Angiotensin II on Tumor Blood Flow and Oxygenation
publication
Author Information
Author(s): Thews O, Kelleher D K, Vaupel P
Primary Institution: Institute of Physiology and Pathophysiology, University of Mainz
Hypothesis
The study investigates how angiotensin II affects tumor perfusion and oxygenation based on tumor size.
Conclusion
The response of tumor blood flow and oxygenation to angiotensin II varies significantly with tumor size.
Supporting Evidence
- In small tumors, red blood cell flux decreases with rising mean arterial blood pressure.
- In larger tumors, red blood cell flux increases with rising mean arterial blood pressure.
- The behavior of tumor blood flow is related to the presence of different types of tumor vessels.
Takeaway
When we give a medicine called angiotensin II to tumors, small tumors get less blood and oxygen, while big tumors get more.
Methodology
The study measured red blood cell flux and oxygen partial pressure in tumors during angiotensin II administration.
Digital Object Identifier (DOI)
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