Effect of nedocromil sodium on polymorphonuclear leukocyte plasma membrane
1994
Effect of Nedocromil Sodium on PMN Membrane Fluidity
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): A. Kantar, N. Oggiano, P. L. Giorgi, V. Coppa, R. Gabbianelli, S. Bruni, R. Fiorini
Primary Institution: University of Ancona
Hypothesis
Nedocromil sodium affects the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs).
Conclusion
Nedocromil sodium significantly decreases the membrane fluidity of PMNs and modulates their activities.
Supporting Evidence
- Nedocromil sodium significantly decreased membrane fluidity of PMNs.
- The decrease in membrane fluidity induced by fMLP was abolished in the presence of nedocromil sodium.
- Nedocromil sodium induced a significant and stable increase in the anisotropy value of TMA-DPH.
Takeaway
Nedocromil sodium makes the membranes of certain white blood cells stiffer, which can change how they work in the body.
Methodology
PMNs were isolated from blood samples and their membrane fluidity was measured using fluorescence techniques.
Participant Demographics
Healthy donors
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
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