FKBP51 protects 661w cell culture from staurosporine-induced apoptosis
2011
FKBP51 Protects Neuronal Cells from Apoptosis
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Donald Daudt, Thomas Yorio
Primary Institution: University of North Texas Health Science Center
Hypothesis
Does increasing FKBP51 protein levels decrease neuronal cell death in response to staurosporine?
Conclusion
FKBP51 protects neuronal cell cultures from apoptosis induced by staurosporine.
Supporting Evidence
- FKBP51 overexpression significantly protected 661w cell cultures from staurosporine-induced apoptosis.
- FK506 treatment significantly protected 661w neuronal cultures from staurosporine-induced apoptosis.
- Both FK506 and FKBP51 appear to act through activation of NF-κB p65 protein.
Takeaway
This study found that a protein called FKBP51 helps keep brain cells alive when they are exposed to a harmful substance, which could help in treating brain diseases.
Methodology
661w cell cultures were treated with FK506 or transfected with FKBP51, then exposed to staurosporine to assess cell viability.
Statistical Information
P-Value
p=0.013
Statistical Significance
p<0.05
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