Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity – a common inflammatory phenotype?
2006
Chronic Obstructive Pulmonary Disease and Inflammation
Commentary
Author Information
Author(s): Martin J Sevenoaks, Robert A Stockley
Primary Institution: Department of Medicine, Queen Elizabeth Hospital Birmingham, UK
Hypothesis
Is there a common inflammatory phenotype linking Chronic Obstructive Pulmonary Disease (COPD) with other systemic diseases?
Conclusion
COPD is associated with systemic inflammation that may contribute to various co-morbidities.
Supporting Evidence
- COPD is a major cause of morbidity and mortality worldwide.
- Inflammation in COPD may lead to muscle wasting and other systemic diseases.
- TNF-α is a central mediator in the inflammatory processes associated with COPD.
Takeaway
COPD can cause inflammation not just in the lungs but also in other parts of the body, which can lead to other health problems.
Digital Object Identifier (DOI)
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