PD1 BLOCKADE IMPROVES SURVIVAL AND CD8+ CYTOTOXIC CAPACITY, WITHOUT INCREASING INFLAMMATION, DURING NORMAL MICROBIAL EXPERIENCE IN OLD MICE
2024
Improving Survival in Old Mice with PD1 Blockade
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Camell Christina
Primary Institution: University of Minnesota
Hypothesis
Can PD1 blockade improve T cell function and survival in old mice during microbial exposure?
Conclusion
PD1 blockade improves survival and T cell function in old mice without increasing inflammation.
Supporting Evidence
- Old SPF mice show increased expression of inflammatory pathways when exposed to microbes.
- Anti-PD1 treatment improves antibody production in old mice.
- Survival improvement is dependent on CD8+ T cells.
Takeaway
This study shows that a treatment can help older mice fight infections better without making them more inflamed.
Methodology
Old specific pathogen-free mice were treated with an anti-PD1 monoclonal antibody during exposure to normal microbial experience.
Participant Demographics
Old specific pathogen-free mice
Digital Object Identifier (DOI)
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