Blocking VEGFR1 and 2 Reduces Abnormal Blood Vessel Growth in the Eye
Author Information
Author(s): Huang Hu, Shen Jikui, Vinores Stanley A., Apte Rajendra S.
Primary Institution: Wilmer Eye Institute, Johns Hopkins University School of Medicine
Hypothesis
This study evaluates the effects of blocking VEGFR1 and 2 on pathological angiogenesis and vascular leakage in ischemic retinopathy.
Conclusion
The study shows that blocking both VEGFR1 and 2 can significantly reduce abnormal blood vessel growth and leakage in models of eye disease.
Supporting Evidence
- Blocking VEGFR1 and 2 reduced choroidal neovascularization by 73±5% and 64±6%, respectively.
- Combination treatment of MF1 and DC101 showed an 85±4% reduction in CNV area.
- Both MF1 and DC101 significantly suppressed retinal neovascularization in oxygen-induced retinopathy.
Takeaway
The researchers found that using special antibodies to block certain signals in the eye can help stop bad blood vessels from growing and leaking.
Methodology
The study used neutralizing antibodies against VEGFR1 and VEGFR2 in mouse models of choroidal neovascularization and oxygen-induced retinal neovascularization.
Limitations
The study did not perform tissue analysis for grossly visible side effects and the fold change of gene expression was moderate.
Participant Demographics
C57BL/6 mice, 6-8 weeks old and pregnant mice.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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