Measuring Blood Supply in Mouse Tumors
Author Information
Author(s): G.M. Baker, M.B. Clarke, W.F. Whimster
Primary Institution: King's College Hospital
Hypothesis
How does the blood supply to tumors in mice change with tumor size?
Conclusion
Small tumors have a higher blood pool compared to larger tumors, but blood flow is generally slower in tumors than in normal tissues.
Supporting Evidence
- Small tumors (under 1 ml) had a blood pool often 2-3 times that of normal tissues.
- Larger tumors (over 1 ml) had a blood pool about 1.5 times that of normal tissues.
- Blood flow in tumors was generally slower than in normal leg tissues.
- Blood pool measurements were significantly higher in tumors under 1 ml compared to larger tumors.
Takeaway
The study looked at how much blood flows to tumors in mice. It found that smaller tumors get more blood than bigger ones, but the blood moves slowly.
Methodology
The study used in vivo red cell labeling with 99mTc-pertechnetate and dynamic scintigraphy to measure blood supply in transplanted tumors in mice.
Potential Biases
Potential bias due to the method of measuring blood flow and the conditions under which measurements were taken.
Limitations
The accuracy of tumor volume measurements may affect the blood pool results.
Participant Demographics
WHT/Ht mice bred by brother-sister mating.
Statistical Information
P-Value
p<0.025
Confidence Interval
95%
Statistical Significance
p<0.025
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