PCNA as a Prognostic Factor in Non-Hodgkin's Lymphoma
Author Information
Author(s): P.J. Klemil, K. Alanen, S. Jalkanen, H. Joensuu
Primary Institution: Turku University Hospital
Hypothesis
The study investigates the prognostic value of PCNA staining in non-Hodgkin's lymphoma.
Conclusion
PCNA staining is associated with survival outcomes in non-Hodgkin's lymphoma, particularly when more than 50% of cells stain positively.
Supporting Evidence
- Lymphomas with >50% PCNA positive cells had a 5-year survival rate of 41%.
- Patients with <50% PCNA positive cells had a 5-year survival rate of 63%.
- PCNA staining was not an independent prognostic factor in multivariate analysis.
Takeaway
If more than half of the lymphoma cells have a certain marker, it can mean a worse outcome for patients.
Methodology
The study involved immunoperoxidase staining of PCNA in lymphoma samples and followed patients for survival outcomes.
Limitations
The study used archival tissue, which may affect staining results.
Participant Demographics
The cohort consisted of 140 patients, with 51% male and a median age of 63 years.
Statistical Information
P-Value
0.008
Statistical Significance
p<0.05
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