Processed Dietary Fiber Increases Risk of Colitis and Colon Cancer in Mice
Author Information
Author(s): Tian Sangshan, Goand Umesh K, Paudel Devendra, Le Giang V., Tiwari Amit K., Prabhu K. Sandeep, Singh Vishal
Primary Institution: The Pennsylvania State University
Hypothesis
Does the consumption of partially hydrolyzed guar gum (Phgg) affect the development of intestinal inflammation and colon cancer in mice?
Conclusion
The study found that Phgg supplementation worsens colitis and promotes colon tumorigenesis in mice.
Supporting Evidence
- Phgg feeding led to increased body weight loss in mice with induced colitis.
- Histological analysis showed significant epithelial damage in Phgg-fed mice.
- Phgg supplementation increased pro-inflammatory markers and decreased anti-inflammatory markers.
- Extensive colon tumorigenesis was observed in Phgg-fed mice in the AOM/DSS model.
Takeaway
Eating a type of fiber called Phgg can make mice sicker and more likely to get colon cancer.
Methodology
Wild-type C57BL/6 mice were fed diets with different levels of Phgg and then induced with colitis and colon cancer using DSS and AOM.
Potential Biases
Potential bias in the interpretation of results due to the specific mouse model used.
Limitations
The study was conducted on mice, which may not fully represent human responses to Phgg.
Participant Demographics
C57BL/6 wild-type mice, both male and female.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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