Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease
2024
Trained Innate Immunity and Preeclampsia's Link to Heart Disease
publication
Evidence: moderate
Author Information
Author(s): Carrasco-Wong Ivo, Sanchez Javiera M., Gutierrez Jaime A., Chiarello Delia I.
Primary Institution: Escuela de Tecnología Médica, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile
Hypothesis
Could trained innate immunity be a mechanism linking preeclampsia to increased cardiovascular risk in mothers?
Conclusion
Preeclampsia may lead to long-term cardiovascular risks in mothers due to trained innate immunity.
Supporting Evidence
- Preeclampsia affects 2-6% of pregnancies and is linked to long-term cardiovascular issues.
- Women with a history of preeclampsia have increased risks of heart failure and coronary heart disease.
- Trained innate immunity may cause a heightened inflammatory response in mothers post-preeclampsia.
Takeaway
Preeclampsia can make mothers more likely to have heart problems later because it changes their immune system in a lasting way.
Limitations
The exact mechanisms linking preeclampsia to cardiovascular risks are still unclear and require further research.
Digital Object Identifier (DOI)
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