New Assay for Measuring Chromogranin A Levels
Author Information
Author(s): Degorce F, Goumon Y, Jacquemart L, Vidaud C, Bellanger L, Pons-Anicet D, Seguin P, Metz-Boutigue M H, Aunis D
Primary Institution: CIS biointernational, Division In Vitro Technologies
Hypothesis
The study aims to develop a new immunoradiometric assay for measuring chromogranin A levels in patients with neuroendocrine tumors.
Conclusion
The new immunoradiometric assay allows for sensitive detection of total human chromogranin A and correlates well with existing methods.
Supporting Evidence
- The study raised 24 monoclonal antibodies against human chromogranin A.
- The new assay correlates well with a reference radioimmunoassay.
- The assay is efficient in measuring CgA levels in patients with neuroendocrine tumors.
Takeaway
Researchers created a new test to measure a protein called chromogranin A, which helps doctors check for certain tumors in patients.
Methodology
The study involved raising 24 monoclonal antibodies against human chromogranin A and testing them against a reference radioimmunoassay.
Digital Object Identifier (DOI)
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