Natural Epithelial Barrier Integrity Enhancers—Citrus medica and Origanum dayi Extracts
Author Information
Author(s): Sarah Coopersmith, Valeria Rahamim, Eliyahu Drori, Rachel Miloslavsky, Rima Kozlov, Jonathan Gorelick, Aharon Azagury, Margareth K.K.D. Franco, Fabiano Yokaichiya
Primary Institution: Ariel University
Hypothesis
This study aimed to evaluate the potential of ethanolic extracts of Citrus medica and Origanum dayi as permeation enhancers for mass transport across the buccal epithelium.
Conclusion
The study found that CMC and ORD extracts may improve and strengthen the integrity of the buccal epithelium, serving as effective alternatives to hyaluronic acid for enhancing buccal cavity health.
Supporting Evidence
- The extracts were non-toxic at concentrations below 0.5% w/v.
- CMC and ORD extracts significantly reduced epithelial permeability of FD40.
- The total phenolic content analysis suggested a link between phenolic concentration and epithelial barrier reinforcement.
- HA was used as a reference for comparing the effects of the extracts.
Takeaway
The researchers tested plant extracts to see if they could help medicine get through the mouth's skin better, but found that some extracts actually made it harder for things to pass through.
Methodology
The study used TR146 cell-based models to assess the effects of ethanolic extracts on buccal epithelium permeability and conducted toxicity tests to evaluate cell viability.
Limitations
The study was limited to in vitro models and did not assess the effects in vivo.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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