Prediction of high-grade cervical intraepithelial neoplasia in cytologically normal women by human papillomavirus testing
2000
HPV Testing for Predicting Cervical Cancer
Sample size: 371
publication
Evidence: high
Author Information
Author(s): Carozzi F, Ronco G, Confortini M, Noferini D, Maddau C, Ciatto S, Segnan N
Primary Institution: Centre for Cancer Study and Prevention (CSPO), Firenze, Italy
Hypothesis
Can HPV testing predict high-grade cervical intraepithelial neoplasia in women with normal cytology?
Conclusion
HPV testing can predict 80% of high-grade cervical lesions three years before cytological diagnosis.
Supporting Evidence
- High-risk HPV was found in 77.17% of smears from cases.
- Only 5.12% of controls had high-risk HPV.
- The odds ratio for HPV presence in cases compared to controls was 63.76.
- HPV positivity declined slightly with increasing latency among cases.
Takeaway
Testing for a virus called HPV can help find serious cervical problems before they show up in regular tests.
Methodology
A case control study using archival cervical smears to identify high-risk HPV.
Participant Demographics
Women from the organized cervical screening programme in Florence, Italy.
Statistical Information
Confidence Interval
95% CI 30.57–132.96
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website