Monitoring Tumor Treatment with Ultrasound in Mice
Author Information
Author(s): Sanjay Tiwari, Jan H. Egberts, Olena Korniienko, Linda Köhler, Anna Trauzold, Claus C. Glüer, Holger Kalthoff
Primary Institution: University Hospital Schleswig-Holstein, Campus Kiel, Germany
Hypothesis
The study aims to assess high resolution sonography imaging for the in vivo monitoring of efficacy of Infliximab in pancreatic tumors.
Conclusion
Infliximab is effective in slowing tumor growth in both primary and resected pancreatic tumors, and high resolution sonography is a sensitive imaging modality for measuring tumor growth.
Supporting Evidence
- Sonography showed that Infliximab slowed tumor growth in both non-resected and resected models.
- Infliximab was more effective at an early stage following tumor resection.
- The study demonstrated that high resolution sonography is a sensitive imaging modality for measuring pancreatic tumor growth.
Takeaway
This study shows that a medicine called Infliximab can help slow down the growth of pancreatic tumors in mice, and we can use special ultrasound pictures to see how well it's working.
Methodology
The study used a mouse model with orthotopic pancreatic tumors, treated with Infliximab, and monitored tumor growth using high resolution sonography.
Limitations
The study was conducted in a mouse model, which may not fully replicate human responses to treatment.
Participant Demographics
Four-week-old female SCID mice weighing 14 to 19 g.
Statistical Information
P-Value
p = 0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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