Evidence of active transport involvement in morphine transport via MDCKII and MDCK-PGP cell lines
2010
How Morphine is Transported in the Body
Sample size: 4
publication
Evidence: moderate
Author Information
Author(s): Mashayekhi S.O., Sattari M.R., Routledge P.A.
Primary Institution: Tabriz University of Medical Sciences
Hypothesis
The study aims to elucidate the transport mechanisms involved in morphine transport via MDCKII and MDCK-PGP cells.
Conclusion
Morphine is a substrate for P-glycoprotein and its transport is influenced by various inhibitors.
Supporting Evidence
- Morphine permeability was significantly higher than sucrose permeability via MDCK II cells.
- Morphine permeability decreased significantly in the presence of digoxin.
- Cyclosporin increased morphine permeability, indicating morphine is a P-GP substrate.
Takeaway
This study shows that morphine can move through certain cells more easily than sugar, and some drugs can change how well it moves.
Methodology
The study used MDCKII and MDCK-PGP cell lines to measure morphine permeability and the effects of various compounds on its transport.
Limitations
The study may not fully represent in vivo conditions as it was conducted in cell lines.
Statistical Information
P-Value
0.0008
Statistical Significance
p<0.001
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