Immune selection in neoplasia: towards a microevolutionary model of cancer development
2000
How Tumors Evolve to Escape the Immune System
publication
Author Information
Author(s): Pettit S J, Seymour K, O'Flaherty E, Kirby J A
Primary Institution: Surgical Immunobiology Group, Department of Surgery, University of Newcastle upon Tyne
Hypothesis
The study explores how tumors adapt to evade the immune system during their development.
Conclusion
Tumors develop adaptations that help them survive against immune responses, indicating the role of immune selection in cancer development.
Supporting Evidence
- Tumors exhibit adaptations that provide growth or survival advantages.
- The study reviews evidence for immune surveillance and immune selection in tumor development.
- Experimental evidence from murine models supports the role of immune involvement in neoplastic development.
Takeaway
Tumors can change and grow in ways that help them hide from our body's defenses, like a game of hide and seek.
Methodology
The study reviews various immunologically relevant adaptations in tumors and their implications for immune response evasion.
Digital Object Identifier (DOI)
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