The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study
2024

Childhood Trauma and Depression in Later Life

Sample size: 6921 publication 10 minutes Evidence: high

Author Information

Author(s): Dai Qianqian, Li Ming, Wang Zhaoyu, Xu Qianqian, Zhang Xinyi, Tao Liyuan, Mohamed Abdel-Latif

Primary Institution: Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China

Hypothesis

Exposure to a higher number of adverse childhood experiences (ACEs) is associated with an increased risk of worsening depressive symptom trajectories, with chronic diseases mediating this relationship.

Conclusion

The study found that adverse childhood experiences are linked to worse depressive symptom trajectories in middle-aged and elderly individuals, with chronic diseases playing a significant mediating role.

Supporting Evidence

  • Approximately 70% of participants reported experiencing at least one adverse childhood experience.
  • Participants with four or more ACEs had a significantly higher likelihood of following adverse trajectories of depressive symptoms.
  • Chronic diseases significantly mediated the relationship between ACEs and depressive symptom trajectories.

Takeaway

If kids go through tough times, they might feel sad when they grow up, especially if they get sick later. Taking care of their health can help them feel better.

Methodology

Data were analyzed from the China Health and Retirement Longitudinal Study (CHARLS) using multinomial logistic regression and group-based trajectory modeling.

Potential Biases

Potential recall bias in reporting adverse childhood experiences.

Limitations

The study relied on retrospective self-reports of ACEs, which may introduce recall bias, and did not account for new-onset chronic diseases from 2011 to 2018.

Participant Demographics

Participants were aged 45 and older, with an average age of 57.2 years, comprising 53.9% females and 46.1% males.

Statistical Information

Confidence Interval

95%CI: 1.126–33.744

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/healthcare12242539

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