Linkage Analysis of TG/HDL-C Ratio in Framingham Heart Study
Author Information
Author(s): Horne Benjamin D, Malhotra Alka, Camp Nicola J
Primary Institution: University of Utah School of Medicine
Hypothesis
Can different linkage analysis methods identify regions associated with the TG/HDL-C ratio in the Framingham Heart Study?
Conclusion
The study found reasonable concordance across different analysis methods, with no single method identifying all regions.
Supporting Evidence
- Fourteen regions with suggestive linkage evidence were identified.
- Ten of the 14 regions were identified by more than one analysis.
- MCLINK performed the best in identifying regions with LODs > 1.0.
Takeaway
Researchers looked at family data to find genes linked to cholesterol levels, and they found some areas that might help understand heart disease risk.
Methodology
Linkage analysis was performed using methods implemented in LINKAGE, GENEHUNTER, MCLINK, and SOLAR on Framingham Heart Study data.
Limitations
The study did not control for smoking, alcohol, physical activity, or lipid-lowering medication use due to data availability.
Participant Demographics
Participants included 2467 individuals from the Framingham Heart Study, with measurements taken primarily in the early 1970s.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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