Prognostic Value of Treatment Response in Colorectal Cancer Liver Metastases
Author Information
Author(s): Bond M.J.G., Mijnals C., Bolhuis K., van Amerongen M.J., Engelbrecht M.R.W., Hermans J.J., van Lienden K.P., May A.M., Swijnenburg R.-J., Punt C.J.A.
Primary Institution: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Hypothesis
Is the prognostic value of RECIST and morphologic response in patients with colorectal cancer liver metastases upon systemic treatment significant?
Conclusion
RECIST response is prognostic for overall survival, while morphologic response is not associated with early recurrence or overall survival.
Supporting Evidence
- RECIST partial response was associated with overall survival.
- Pathological response was significantly associated with early recurrence.
- Major pathological response was associated with longer survival.
Takeaway
Doctors looked at how well treatments worked for patients with liver cancer from the colon. They found that one way of measuring success (RECIST) was helpful, but another way (morphologic response) wasn't.
Methodology
The study analyzed data from 489 patients in the CAIRO5 trial who received various systemic treatments and evaluated their responses using RECIST and morphologic criteria.
Potential Biases
Potential interobserver variability in assessing treatment responses could introduce bias.
Limitations
The study's findings may not apply to patients with different treatment regimens or those not included in the trial.
Participant Demographics
{"age":{"median":62,"IQR":"54-69"},"sex":{"female":185,"male":304},"performance_status":{"0":316,"1":170,"2":2},"primary_tumor_sidedness":{"left":363,"right":126},"time_to_metastases":{"metachronous":51,"synchronous":438},"prior_adjuvant_chemotherapy":{"no":468,"yes":21},"prior_radiotherapy":{"no":423,"yes":66},"RAS_mutation":{"no":253,"yes":236},"BRAFV600E_mutation":{"no":460,"yes":29},"total_liver_metastases":{"median":12,"IQR":"7-22"},"largest_liver_metastasis_size":{"median":41,"IQR":"27-66"}}
Statistical Information
P-Value
p<0.001
Confidence Interval
{"overall_survival":"95% CI 0.44-0.99"}
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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