Dangkwisoo-San Protects the Brain from Ischemic Injury
Author Information
Author(s): Kim Ji Hyun, Park Sun Haeng, Kim Young Whan, Ha Jung Min, Bae Sun Sik, Lee Guem San, Cho Su In, Choi Byung Tae, Shin Hwa Kyoung
Primary Institution: Pusan National University
Hypothesis
Does Dangkwisoo-San have protective effects against cerebral ischemic injury through nitric oxide-dependent mechanisms?
Conclusion
Dangkwisoo-San significantly reduces cerebral infarct size and improves blood flow in a mouse model of ischemic stroke.
Supporting Evidence
- Dangkwisoo-San increased nitric oxide production in human brain microvascular endothelial cells.
- DS reduced cerebral infarct size by 53.7% compared to vehicle treatment.
- DS caused vasodilation in isolated mouse aorta through a nitric oxide-dependent mechanism.
- DS improved resting cerebral blood flow in a concentration-dependent manner.
- DS treatment increased phosphorylation of eNOS in the brains of treated mice.
Takeaway
Dangkwisoo-San is a herbal medicine that helps protect the brain from damage during a stroke by improving blood flow.
Methodology
Mice were treated with Dangkwisoo-San before inducing ischemia, and various physiological parameters were measured.
Limitations
The study was conducted in a mouse model, which may not fully replicate human conditions.
Participant Demographics
C57/BL6J mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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