Periodontal Disease and Atherosclerosis: A Study on Their Relationship
Author Information
Author(s): Miyaki Koichi, Masaki Katsunori, Naito Mariko, Naito Toru, Hoshi Keika, Hara Asako, Tohyama Shugo, Nakayama Takeo
Primary Institution: Keio University, Tokyo, Japan
Hypothesis
Is periodontal disease an independent risk factor for the development of atherosclerosis?
Conclusion
The study found no relationship between mild periodontal disease and atherosclerosis after appropriate adjustments.
Supporting Evidence
- The unadjusted odds ratio of atherosclerosis in relation to the CPITN score was 1.41.
- After adjustment for age, the CPITN score had no relationship with atherosclerosis.
- The study used baPWV as a non-invasive marker of vascular damage.
Takeaway
This study looked at whether gum disease can cause heart problems, but it found that mild gum disease doesn't seem to affect heart health.
Methodology
A cross-sectional study assessing periodontal disease severity using CPITN scores and atherosclerosis using baPWV in 291 healthy male workers.
Potential Biases
Potential confounding factors such as age, systolic blood pressure, and smoking were adjusted for, but imperfect measurement of confounders may still exist.
Limitations
The sample size was relatively small, and the cross-sectional design did not allow for causal relationships to be established.
Participant Demographics
291 healthy male workers from a Japanese chemical company, mean age 46.6 years.
Statistical Information
P-Value
0.029
Confidence Interval
[0.68–1.20]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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